Key result
Liver-specific knockout of angiotensinogen markedly reduced renal angiotensin II content to 13% of control levels (median 46 vs 362 fmol/g tissue), whereas kidney-specific knockout had no effect.
Population
Mouse models including kidney-specific angiotensinogen knockout mice, liver-specific angiotensinogen…
Comparison
Genetic knockout of angiotensinogen, megalin… vs Control mice
Design
Preclinical
Authors
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Liver-derived angiotensinogen supplies most renal angiotensin II in mice; leaves open relevance to human proteinuric kidney disease.
Absolute Event Rate: 46% vs 362%
p-value: p=<0.01
Liver-derived angiotensinogen is the primary source of renal angiotensin II, and increased glomerular permeability in proteinuric kidney diseases enhances its synthesis.
Matsusaka et al. (2012) studied Renal Angiotensin II generation. Liver-specific angiotensinogen knockout vs. Control mice (Agt loxP/loxP without Cre) was evaluated on Renal angiotensin II content (fmol/g tissue) (p=<0.01). Liver-specific knockout of angiotensinogen markedly reduced renal angiotensin II content to 13% of control levels (median 46 vs 362 fmol/g tissue), whereas kidney-specific knockout had no effect.
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