Key result
Black hypertensive patients treated with quinapril had a 2.3 mm Hg smaller reduction in systolic blood pressure compared to white patients after covariate adjustment.
Why the study?
Does race independently determine blood pressure response to quinapril monotherapy in hypertensive patients?
Population
2,579 hypertensive patients (533 black and 2046 white participants)
Comparison
Quinapril monotherapy vs White participants receiving quinapril monotherapy
Design
Cohort
Authors
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Racial difference in quinapril response after adjustment should not change prescribing; leaves open whether race independently predicts ACEI efficacy.
Observational (n=2,579)
Does race independently determine blood pressure response to quinapril monotherapy in hypertensive patients?
Mean Difference: 2.3
Individual patient characteristics, such as age, gender, body size, and baseline blood pressure severity, account for a substantial portion of the apparent racial differences in blood pressure response to ACE inhibitors.
Mokwe et al. (2004) conducted an observational in Hypertension (n=2,579). Black race vs. White race was evaluated on Systolic blood pressure response to treatment (baseline minus follow-up) (MD 2.3 mm Hg). Black hypertensive patients treated with quinapril had a 2.3 mm Hg smaller reduction in systolic blood pressure compared to white patients after covariate adjustment.
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