February 1, 1993Journal of Cardiovascular Pharmacology
Efficacy and Safety of Various Combination Therapies Based on a Calcium Antagonist in Essential Hypertension
Why the study?
Do various combination therapies reduce blood pressure in hypertensive patients uncontrolled on isradipine monotherapy?
Population
550 hypertensive patients with uncontrolled blood pressure on isradipine 2.5 mg b.i.d. monotherapy
Comparison
Bopindolol 0.5 or 1 mg/day, metolazone 1.25 or… vs Placebo added to isradipine 2.5 mg b.i.d.
Design
RCT, randomly assigned
Authors
Discussion
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Implication
Supports adding beta-blocker, diuretic, or ACE inhibitor to isradipine; confirms efficacy of combination therapy in uncontrolled hypertension.
Structured PICO
Do various combination therapies reduce blood pressure in hypertensive patients uncontrolled on isradipine monotherapy?
P
Population
550 hypertensive patients with uncontrolled blood pressure (diastolic BP > 90 mm Hg) on isradipine 2.5 mg b.i.d. monotherapy (out of 1,647 initially enrolled)
I
Intervention
Bopindolol 0.5 or 1 mg/day, metolazone 1.25 or 2.5 mg/day, enalapril 10 or 20 mg/day, or isradipine 5 mg b.i.d. added to isradipine 2.5 mg b.i.d.
C
Comparator
Placebo added to isradipine 2.5 mg b.i.d.
O
Outcome
Reduction in systolic and diastolic blood pressuresurrogate
In patients with hypertension uncontrolled on calcium antagonist monotherapy, adding a beta-blocker, diuretic, or ACE inhibitor effectively lowers blood pressure with minor side effects.
Cite This Study
Lüscher et al. (1993) studied this question.