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January 1, 1997Arteriosclerosis Thrombosis and Vascular Biology

Polymorphism of the Apolipoprotein E Gene and Early Carotid Atherosclerosis Defined by Ultrasonography in Asymptomatic Adults

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Why the study?

Does the apolipoprotein E4 allele increase carotid intima-media thickness in asymptomatic nondiabetic adults compared to E3 and E2 alleles?

Population

260 asymptomatic nondiabetic adults, mean age 53 +/- 7 years, randomly selected from the population register…

Comparison

Apolipoprotein E (apoE) E4 allele carrier status vs Apolipoprotein E E3 and E2 allele carrier status

Design

Cross-sectional

Authors

LCLuigi CattinMFM. FisicaroMTMaurizio Tonizzo

Discussion

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Overview

Supports apoE4 as atherosclerosis marker beyond lipids; hypothesis-generating, should not yet change practice.

Structured PICO

Does the apolipoprotein E4 allele increase carotid intima-media thickness in asymptomatic nondiabetic adults compared to E3 and E2 alleles?

P
Population
260 asymptomatic nondiabetic adults (121 men, 139 women), mean age 53 +/- 7 years, randomly selected from the population register of Trieste, Italy.
I
Intervention
Apolipoprotein E (apoE) E4 allele carrier status
C
Comparator
Apolipoprotein E (apoE) E3 and E2 allele carrier status
O
Outcome
Carotid intima-media thickness (IMT) assessed by B-mode ultrasoundsurrogate

The apoE4 genotype is associated with increased early carotid atherosclerosis (measured by IMT) in middle-aged asymptomatic subjects, independent of lipid levels.

Cite This Study

Cattin et al. (1997) studied this question.

synapsesocial.com/papers/6a8309acc009eb9b7eefe01dhttps://doi.org/10.1161/01.atv.17.1.91
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