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October 1, 1996Stroke

Apolipoprotein E Polymorphism Is Associated With Segment-Specific Extracranial Carotid Artery Intima-Media Thickening

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Why the study?

Is Apolipoprotein E (apoE) polymorphism associated with carotid artery intima-media thickening in individuals with and without CAD?

Population

260 individuals equally represented by angiographically determined CAD case subjects and disease-free…

Comparison

Apolipoprotein E polymorphism vs Comparison between different apoE phenotypes

Design

Case-control

Authors

JTJames G. TerryGHGeorge HowardMMMichele Mercuri

Discussion

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Overview

ApoE variants may modulate carotid atherosclerosis beyond LDL; hypothesis-generating for genetic risk stratification pending prospective validation.

Structured PICO

Is Apolipoprotein E (apoE) polymorphism associated with carotid artery intima-media thickening in individuals with and without CAD?

P
Population
260 individuals equally represented by angiographically determined CAD case subjects and disease-free control subjects
I
Intervention
Apolipoprotein E (apoE) polymorphism (E2, E3, or E4 phenotypes)
C
Comparator
Comparison between different apoE phenotypes
O
Outcome
Carotid artery intima-media thickening (IMT) evaluated by B-mode ultrasoundsurrogate

ApoE polymorphism is independently associated with segment-specific carotid intima-media thickening, suggesting a genetic influence on atherosclerosis risk beyond LDL cholesterol levels.

Cite This Study

Terry et al. (1996) studied this question.

synapsesocial.com/papers/6a79c466756812e39589415ehttps://doi.org/10.1161/01.str.27.10.1755
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polymorphism of the Apolipoprotein E Gene and Early Carotid Atherosclerosis Defined by Ultrasonography in Asymptomatic Adults1997 · 115 citations
  2. 2Carotid intima-media thickness in the first descendant of coronary artery disease patients with Apolipoprotein-E4 genotype2022 · 2 citations
  3. 3Association between the apolipoprotein E polymorphism and arterial wall thickness in asymptomatic adults2000 · 35 citations
  4. 4New Insight Into the Association of Apolipoprotein E Genetic Variants With Carotid Plaques and Intima-Media Thickness2006 · 31 citations
  5. 5Apolipoprotein E and Carotid Artery Atherosclerosis2001 · 82 citations