Why the study?
APO-E4 polymorphism is considered a genetic determinant of atherosclerosis and CAD, motivating evaluation of APO-E gene polymorphisms and carotid intima thickness in first descendants of coronary heart disease patients.
Is the APO-E4 genotype associated with increased carotid intima-media thickness in the first descendants of CAD patients?
Population
First descendants of CAD and non-CAD groups (21 samples in each group)
Comparison
First descendants of CAD vs non-CAD parents, or APO-E4 vs non-APO-E4 genotype
Design
Cross-sectional study
Key result
The APO-E4 genotype was associated with a significantly higher mean carotid intima-media thickness compared to the non-APO-E4 genotype (0.4743 mm vs. 0.4195 mm; P=0.017).
Authors
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May flag higher subclinical atherosclerosis risk in CAD offspring; hypothesis-generating and requires prospective validation before any clinical role.
Cross-Sectional (n=42)
Is the APO-E4 genotype associated with increased carotid intima-media thickness in the first descendants of CAD patients?
Absolute Event Rate: 0.4743% vs 0.4195%
p-value: p=0.017
The APO-E4 genotype is associated with increased subclinical atherosclerosis (measured by CIMT) in the first descendants of CAD patients.
Prayogo et al. (2022) conducted a cross-sectional in First descendant of coronary artery disease patients (n=42). APO-E4 genotype vs. non-APO-E4 genotype was evaluated on Carotid intima-media thickness (CIMT) (p=0.017). The APO-E4 genotype was associated with a significantly higher mean carotid intima-media thickness compared to the non-APO-E4 genotype (0.4743 mm vs. 0.4195 mm; P=0.017).