Key result
Among hypertensive smokers, carriers of the apoE 4 allele had significantly greater mean carotid intima-media thickness compared to non-carriers (1.01 vs 0.90 mm, P=0.003).
Why the study?
Does the apolipoprotein E 4 allele interact with smoking to increase carotid artery intima-media thickness in hypertensive men?
Population
511 hypertensive and control men
Comparison
Apolipoprotein E 4 allele carrier status and… vs Non-carriers of apoE 4 allele and non-smokers
Design
Cross-sectional
Authors
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May flag higher-risk hypertensive smokers; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=511)
Does the apolipoprotein E 4 allele interact with smoking to increase carotid artery intima-media thickness in hypertensive men?
Mean Difference: 0.088
Absolute Event Rate: 1.01% vs 0.9%
p-value: p=<0.001
The apolipoprotein E 4 allele interacts with smoking to significantly increase carotid artery intima-media thickness, particularly in hypertensive men, suggesting a genetic susceptibility to the atherogenic effects of smoking.
Karvonen et al. (2002) conducted a cross-sectional in Hypertension (n=511). apoE 4 allele vs. Genotypes without the apoE 4 allele was evaluated on Mean carotid intima-media thickness (IMT) in hypertensive smokers (MD 0.088 mm, p=<0.001). Among hypertensive smokers, carriers of the apoE 4 allele had significantly greater mean carotid intima-media thickness compared to non-carriers (1.01 vs 0.90 mm, P=0.003).
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