Key result
Apolipoprotein E genotype lacking the epsilon4 allele was associated with greater mean carotid intima-medial thickness (beta=-0.139, P=0.023) in untreated hypertensive men.
Why the study?
Does apolipoprotein E polymorphism predict carotid intima-medial thickness and plaque in untreated hypertensive men?
Population
182 untreated, hypertensive, white men (mean age 56+/-8.9 years)
Comparison
Apolipoprotein E genotype with no ε4 allele vs Apolipoprotein E genotype with any ε4 allele
Design
Cross-sectional
Authors
Loading...
Suggests ε3 allele as potential genetic marker for carotid atherosclerosis in untreated hypertensive men; leaves open prospective validation.
Observational (n=182)
Does apolipoprotein E polymorphism predict carotid intima-medial thickness and plaque in untreated hypertensive men?
Effect estimate: beta=-0.139
p-value: p=0.023
In untreated hypertensive men, the apolipoprotein E ε3 allele, rather than the ε4 allele, is associated with greater carotid intima-medial thickness, suggesting a specific genetic risk for carotid atherosclerosis.
Bleil et al. (2006) conducted an observational in Hypertension and preclinical carotid artery disease (n=182). Apolipoprotein E (apoE) polymorphism (no epsilon4 allele) vs. Any epsilon4 allele was evaluated on Mean carotid intima-medial thickness (beta=-0.139, p=0.023). Apolipoprotein E genotype lacking the epsilon4 allele was associated with greater mean carotid intima-medial thickness (beta=-0.139, P=0.023) in untreated hypertensive men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: