Population
Cardiac muscle cells in culture
Comparison
Serum removal and refeeding vs High concentration of serum vs no serum
Design
Preclinical
Authors
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Hypothesis-generating in rodent cardiogenesis; leaves open BBF-1 relevance to human cardiac differentiation or therapy.
Identification of BBF-1, a novel serum-responsive, cardiac-specific transcription factor in the MEF-2 family, provides insights into the regulatory mechanisms underlying cardiogenic differentiation.
Zhou et al. (1993) studied this question.