Serum lipoprotein ECE exhibits metalloproteinase- and chymotrypsin-like properties and may be involved in processing big ET-1 to ET-1 in the circulatory system.
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Lipoprotein ECE activity in animal serum is hypothesis-generating for circulatory ET-1 production; leaves open relevance to human cardiovascular disease.
Ohwaki et al. (1993) studied this question.
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