Key result
Adrenaline-induced acute hypertension resulted in significantly larger leakage of human serum albumin into the brains of awake rats compared to noradrenaline or angiotensin.
Adrenaline-induced acute hypertension causes greater blood-brain barrier disruption than noradrenaline or angiotensin in rats, likely due to beta-adrenergic stimulation.
Does not support altering vasopressor selection in humans; leaves open differential catecholamine effects on blood-brain barrier permeability.
Acute hypertension was induced by adrenaline, noradrenaline or angiotensin in awake unrestrained rats with chronic indwelling catheters in a jugular vein and in the aorta. The leakage of 125IHSA (human serum albumin) into the brains from rats given adrenaline was significantly larger than in the brains from rats given noradrenaline or angiotensin. It is likely that the enhanced vulnerability of the blood-brain barrier to an adrenaline-induced increase in blood pressure is due to the beta-adrenergic stimulating effect of adrenaline.
No takes yet. Share an insight, caveat, or question.
Johansson et al. (2009) studied Acute hypertension. Adrenaline vs. Noradrenaline or angiotensin was evaluated on Leakage of 125IHSA (human serum albumin) into the brains. Adrenaline-induced acute hypertension resulted in significantly larger leakage of human serum albumin into the brains of awake rats compared to noradrenaline or angiotensin.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: