What question did this study set out to answer?

Synthesize current evidence regarding the sensory and signaling roles of primary cilia and centrosomes in skeletal muscle development, progenitor cell dynamics, and tissue regeneration.

September 4, 2021International Journal of Molecular SciencesOpen Access

Cilia, Centrosomes and Skeletal Muscle

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Synthesize current evidence regarding the sensory and signaling roles of primary cilia and centrosomes in skeletal muscle development, progenitor cell dynamics, and tissue regeneration.
Reviewed cellular and molecular studies examining primary cilia structure and ciliogenesis in muscle progenitor lineages.
Synthesized mechanistic findings on cilia-mediated signaling during myoblast differentiation, myofiber formation, and fibro-adipogenic progenitor regulation.
Primary cilia on muscle stem cells orchestrate cell cycle progression, promote differentiation, and disassemble during fusion while leaving functional remnants in mature myotubes.
Cilia on fibro-adipogenic progenitors direct cell fate autonomously and non-autonomously, modulating muscle regeneration and preventing pathological fibrosis during aging and disease.

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Implication

Narrative review uncovers essential signaling functions of primary cilia in skeletal muscle progenitors, highlighting their critical regulation of myogenesis, tissue repair, and aging.

Cite This Study

Ng et al. (2021) studied this question.

synapsesocial.com/papers/6a830c7886395db871b38294 https://doi.org/10.3390/ijms22179605

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Implication

Narrative review uncovers essential signaling functions of primary cilia in skeletal muscle progenitors, highlighting their critical regulation of myogenesis, tissue repair, and aging.

Cilia, Centrosomes and Skeletal Muscle

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Implication

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Cilia, Centrosomes and Skeletal Muscle

Key Points

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Implication

Cite This Study

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