What does this research mean for the field?

The primary cilium actively regulates signaling pathways essential for the maintenance of muscle stem cell quiescence, proliferation, mechano-sensation, and fate decision during skeletal muscle regeneration. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To synthesize current knowledge and recent advances regarding how the primary cilium acts as a sensory organelle to regulate muscle stem cell function and skeletal muscle regeneration.

September 14, 2026Stem Cell Reviews and ReportsOpen Access

The Primary Cilium: A New Player in Muscle Stem Cell Biology

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Authors

ATAnna Rausch de TraubenbergUniversité Claude Bernard Lyon 1 LRLudivine RotardUniversité Claude Bernard Lyon 1 CBCaroline BrunUniversité Claude Bernard Lyon 1

Discussion

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Implication

Narrative review reveals the sensory role of primary cilia in muscle stem cells, highlighting their regulation of quiescence, mechanosensation, and tissue repair.

Key Points

To synthesize current knowledge and recent advances regarding how the primary cilium acts as a sensory organelle to regulate muscle stem cell function and skeletal muscle regeneration.
Literature review evaluating molecular, mechanical, and cellular mechanisms of primary cilia function in quiescent, activated, and self-renewing adult skeletal muscle stem cells.
Primary cilia function as cellular signaling hubs that sense both biochemical molecules and mechanical forces to preserve the quiescent state of adult muscle stem cells.
Ciliary signaling dynamically orchestrates stem cell activation following skeletal muscle injury and guides cell fate decisions during asymmetric self-renewal.

Cite This Study

Traubenberg et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3d00926e14a848b2fa1 https://doi.org/10.1007/s12015-026-11233-2

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September 14, 2026Stem Cell Reviews and ReportsOpen Access

The Primary Cilium: A New Player in Muscle Stem Cell Biology

View Full Paper

Ask AI

Bookmark

Authors

ATAnna Rausch de TraubenbergUniversité Claude Bernard Lyon 1 LRLudivine RotardUniversité Claude Bernard Lyon 1 CBCaroline BrunUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Narrative review reveals the sensory role of primary cilia in muscle stem cells, highlighting their regulation of quiescence, mechanosensation, and tissue repair.

Key Points

To synthesize current knowledge and recent advances regarding how the primary cilium acts as a sensory organelle to regulate muscle stem cell function and skeletal muscle regeneration.
Literature review evaluating molecular, mechanical, and cellular mechanisms of primary cilia function in quiescent, activated, and self-renewing adult skeletal muscle stem cells.
Primary cilia function as cellular signaling hubs that sense both biochemical molecules and mechanical forces to preserve the quiescent state of adult muscle stem cells.
Ciliary signaling dynamically orchestrates stem cell activation following skeletal muscle injury and guides cell fate decisions during asymmetric self-renewal.

Cite This Study

Traubenberg et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3d00926e14a848b2fa1 https://doi.org/10.1007/s12015-026-11233-2

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