Key result
Pin1 overexpression, associated with rs2233678 and rs2287839 genotypes, was identified as a potential pathogenic factor for early-onset NAFLD in a 38-year-old male.
Why the study?
The study was conducted to explore a novel genetic and molecular basis of nonalcoholic fatty liver disease (NAFLD).
Do specific Pin1 SNPs and elevated plasma Pin1 predict early-onset NAFLD risk?
Case Report (n=1)
Do specific Pin1 SNPs and elevated plasma Pin1 predict early-onset NAFLD risk?
Elevated plasma Pin1 and specific SNPs (rs2233678 and rs2287839) may serve as novel genetic biomarkers for early-onset NAFLD risk.
Hypothesis-generating for Pin1 SNPs as early-onset NAFLD biomarkers; does not support clinical use without validation.
OBJECTIVE: A novel genetic and molecular basis of nonalcoholic fatty liver disease (NAFLD) was explored. STUDY DESIGN: A 38-year-old male, who has no bad living and dietary habits, was diagnosed as NAFLD. The potential pathogenic role of Pin1 was evaluated by enzyme-linked immunosorbent (ELISA) assay and single nucleotide polymorphism (SNP) sequencing. RESULTS: SNPs were sequenced and classified according to their NAFLD-pathogenic risks, suggesting that rs2233678 and rs2287839 may be the most important genotypes that result in Pin1 overexpression and NAFLD development. CONCLUSION: In summary, this work explores a novel basis for early-onset NAFLD and highlights that elevated plasma Pin1 may predict NAFLD risk at early stage. Hypothetically, inhibiting Pin1 may benefit NAFLD prevention in the future.
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Wang et al. (2019) conducted a case report in Nonalcoholic fatty liver disease (NAFLD) (n=1). Pin1 overexpression and SNPs (rs2233678 and rs2287839) was evaluated on Pin1 overexpression and NAFLD development. Pin1 overexpression, associated with rs2233678 and rs2287839 genotypes, was identified as a potential pathogenic factor for early-onset NAFLD in a 38-year-old male.
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