Key result
The 5' UTRs of the insulin receptor and insulin-like growth factor receptor promote translation initiation independently of the canonical translation factor eIF4G1.
Why the study?
Under stress conditions with global translation repression, certain transcripts like Insr and Igf1r remain actively translated via IRES elements, requiring a different repertoire of factors than canonical cap-dependent translation.
Population
Insr and Igf1r cellular transcripts in vitro and in cells
Comparison
Treatments inhibiting canonical translation factor eIF4G1 vs uninhibited conditions
Design
In vitro and cellular laboratory study
Authors
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Insr/Igf1r IRES activity persists without eIF4G1; hypothesis-generating for stress-resistant cardiac insulin signaling, needing in vivo confirmation.
The Insr and Igf1r transcripts contain cellular IRES elements that facilitate translation initiation independently of intact eIF4G1, allowing them to function under stress conditions when canonical translation is repressed.
Clark et al. (2022) studied this question. eIF4G1 depletion or inhibition vs. Mock treatment or control was evaluated on Translation activity of Insr and Igf1r IRES reporters. The 5' UTRs of the insulin receptor and insulin-like growth factor receptor promote translation initiation independently of the canonical translation factor eIF4G1.
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