Primary chicken embryo cell cultures are a viable alternate cell system for producing stable attenuated Venezuelan equine encephalomyelitis (TC-83 strain) vaccine.
Stability of TC-83 in chicken embryo cells supports alternate production systems; leaves open translation to human vaccine manufacturing.
Primary chicken embryo cell cultures were evaluated a s an alternate cell system for the production of attenuated Venezuelan equine encephalomyelitis (TC-83 strain) vaccine. The TC-83 strain virus was shown to remain stable during 10 serial passages in chicken embryo cell culture with regard to plaque size and morphology, virus yield, potency, and virulence for mice and hamsters.
No takes yet. Share an insight, caveat, or question.
Cole et al. (1976) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: