Key result
Intensive glycemic control has controversial benefits for reducing cardiovascular complications in type 2 diabetes, though early intervention and multifactorial risk factor control are beneficial.
Why the study?
Despite epidemiological evidence that poor glycemic control increases cardiovascular events in T2DM, intervention trials remain inconclusive.
Does intensive glycemic control reduce cardiovascular outcomes in patients with diabetes mellitus?
Does intensive glycemic control reduce cardiovascular outcomes in patients with diabetes mellitus?
Cardiovascular protection in diabetes requires a multifactorial approach including individualized glycemic targets to balance the benefits of intensive control against the risks of hypoglycemia.
Supports individualized glycemic targets in T2D to balance benefits against hypoglycemia risks; leaves open optimal intensity for CV protection.
Diabetes is a well-known cardiovascular risk factor in both T1DM and T2DM. They have a 4-10 higher risk of developing complications from CVD than the non-diabetic population. The importance of intensive glycaemic control to prevent CVD in T1DM was established in both “The Diabetes Control and Complication Trial” (DCCT) and “Epidemiology of Diabetes Intervention and Complications” (EDIC) trials. Despite the epidemiological evidence that poor glycaemic control can lead to higher incidence of cardiovascular events in T2DM, the intervention trials are still inconclusive. In this report we will highlight the pathophysiology of the effect of hyperglycemia on the cardiovascular system, the effect of medications, and the major Randomized Control Trials (RCTs) looking specifically at the cardiovascular outcome of intensive glycaemic control in T2DM. Chatt Maa Shi Hosp Med Coll J; Vol.19 (2); July 2020; Page 50-56
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Chowdhury et al. (2020) conducted a review in Type 1 and Type 2 Diabetes Mellitus. Intensive glycemic control vs. Standard glycemic control was evaluated. Intensive glycemic control has controversial benefits for reducing cardiovascular complications in type 2 diabetes, though early intervention and multifactorial risk factor control are beneficial.
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