Key result
Young males with masked arterial hypertension had nearly twice the level of noradrenaline (19.5 pM/L) compared to normotensive individuals (8.0 pM/L), indicating hypersympathicotonia.
Cross-Sectional (n=643)
No
Masked arterial hypertension is more prevalent than manifest hypertension in young males and is associated with hypersympathicotonia and behavioral risk factors.
Suggests sympathetic assessment in young males with masked hypertension; leaves open causal role and therapeutic implications.
Aim . To assess the neurohumoral state, specifics of clinical presentation, prevalence and prominence of cardiovascular and behavioral risk factors in males of young age with masked arterial hypertension (MAH). Material and methods . To the full coverage screening study, 643 participants included, age 18-30 y. o. (mean age 22). Complete clinical and laboratory, instrumental assessments performed, with analysis of neurohumoral activity by the levels of adrenaline, noradrenaline, angiotensin II. All participants were selected to groups: MAH (n=61), manifest AH (n=46), normotonics (n=536). Diagnostics of MAH was done in case of positive test of 30 second respiration pause and 24 hour blood pressure (BP) monitoring. Results. In males, MAH was found in 9,5% cases, manifest AH in 7,1%, normotonia in 83,4%. In MAH and manifest AH participants the level of adrenaline was higher than in normotonics: 4,55 pM/L [3,53; 5,1], 6,25 pM/L [4,75; 8,65] and 2,1 pM/L [1,2; 4,5], respectively. Males with MAH had almost 2 times higher level of noradrenaline (19,5 pM/L [18,8; 22,8]) comparing to “normotonics” (8 pM/L [6; 12,1]) and 1,5 times higher than in manifest AH (13,1 pM/L [11,5; 14,4]). Angiotensin II assessment showed that in MAH males it was higher (18,5 pM [15,75; 21,9]), than in normotonics (15,7 pM [13;18,3]), but lower than in manifest AH (20,15 pM [18,9; 21,9]). Food related behavior assessment as of a factor of sodium overconsumption, the higher values were found in MAH patients and in manifest AH (50% and 50%) comparing to normotonics (25%). Early age of smoking beginning found in 28% of MAH males, more prevalent than in normotonics (24%) and manifest AH (15%). Conclusion . In young males MAH is revealed more often than manifest AH. Development of MAH in young males is related to hypersympathicity with raised catecholamines level, disordered 24 hour rhythm “non-dipper”, disorder of BP variability and higher smoking level, than in normotonics.
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Lyamina et al. (2018) conducted a cross-sectional in Masked arterial hypertension (n=643). Masked arterial hypertension vs. Normotension was evaluated on Noradrenaline level (pM/L). Young males with masked arterial hypertension had nearly twice the level of noradrenaline (19.5 pM/L) compared to normotensive individuals (8.0 pM/L), indicating hypersympathicotonia.
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