Key result
Adding ivabradine to optimal medical therapy in four patients with nonischemic cardiomyopathy and left bundle branch block resulted in reverse electrical and mechanical remodeling.
Why the study?
Does adding ivabradine to optimal medical therapy improve reverse electrical and mechanical remodeling in patients with chronic heart failure caused by nonischemic cardiomyopathy with left bundle branch block?
Case Report (n=4)
Does adding ivabradine to optimal medical therapy improve reverse electrical and mechanical remodeling in patients with chronic heart failure caused by nonischemic cardiomyopathy with left bundle branch block?
Ivabradine may promote reverse electrical and mechanical remodeling in patients with nonischemic cardiomyopathy and left bundle branch block.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating in nonischemic cardiomyopathy with LBBB; does not support practice change without randomized trials.
Left bundle branch block increases the risk of death in patients with chronic heart failure. We herein report four clinical cases of patients with chronic heart failure caused by nonischemic cardiomyopathy with left bundle branch block that occurred when adding ivabradine to optimal medical therapy, resulting in reverse electrical and mechanical remodeling. This phenomenon might be explained by the effect of ivabradine on reverse remodeling of the left ventricle with improvement of intraventricular conduction.
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Kučerová et al. (2018) conducted a case report in Chronic heart failure caused by nonischemic cardiomyopathy with left bundle branch block (n=4). Ivabradine was evaluated on Reverse electrical and mechanical remodeling. Adding ivabradine to optimal medical therapy in four patients with nonischemic cardiomyopathy and left bundle branch block resulted in reverse electrical and mechanical remodeling.
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