Key result
Evidence of human herpesvirus-8 infection was found in the lung tissue and plexiform lesions of one of two patients with both primary pulmonary hypertension and Castleman's disease.
Why the study?
Is there an association between human herpesvirus-8 infection and the co-occurrence of primary pulmonary hypertension and Castleman's disease?
Case Report (n=2)
Is there an association between human herpesvirus-8 infection and the co-occurrence of primary pulmonary hypertension and Castleman's disease?
This case series suggests a potential angio-proliferative link via human herpesvirus-8 infection in patients with co-occurring primary pulmonary hypertension and Castleman's disease.
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May support HHV-8 link in rare primary pulmonary hypertension–Castleman's overlap; hypothesis-generating and requires confirmation before clinical consideration.
Bull et al. (2003) conducted a case report in Primary pulmonary hypertension and Castleman's disease (n=2). Human herpesvirus-8 infection was evaluated on Evidence of human herpesvirus-8 infection in lung tissue. Evidence of human herpesvirus-8 infection was found in the lung tissue and plexiform lesions of one of two patients with both primary pulmonary hypertension and Castleman's disease.
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