Key result
Among overweight and obese adults without diabetes or hypertension, the prevalence of microalbuminuria was 11% and significantly increased with higher body mass index (P=0.04) and waist-to-hip ratio >1 (P=0.02).
Why the study?
Diabetes, hypertension, and obesity are associated with endothelial dysfunction, with microalbuminuria being its first sign, prompting evaluation of urine albumin-to-creatinine ratio in obese patients without diabetes and with normal blood pressure.
Is there an association between obesity indices (BMI and WHR) and the prevalence of microalbuminuria in non-diabetic, normotensive adults?
Cross-Sectional (n=200)
No
Is there an association between obesity indices (BMI and WHR) and the prevalence of microalbuminuria in non-diabetic, normotensive adults?
p-value: p=0.04
Higher BMI and waist-to-hip ratio are significantly associated with an increased prevalence of microalbuminuria in non-diabetic, normotensive adults, suggesting early endothelial dysfunction in obesity.
Microalbuminuria may signal early endothelial dysfunction in obese non-diabetics; hypothesis-generating, longitudinal studies needed before screening implications.
Introduction : Diabetes, hypertension and obesity are associated with endothelial dysfunction. The first sign of endothelial dysfunction is microalbuminuria. Objectives : The aim of this study was to measure urine albumin to creatinine ratio in obese patients without diabetes and with normal blood pressure. Patients and Methods : In this cross-sectional study, 200 adults were chosen with body mass index (BMI) ≥25 kg/m2 . Anthropometry measurements [BMI and waist to hip ratio (WHR)] and biochemical tests were performed. Data were analyzed using chi-square test, analysis of variance (ANOVA), and Pearson’s correlation coefficient. Results : Among 200 obese people, microalbuminuria was seen in 22 individuals (11%). The prevalence of microalbuminuria was positively increased with increasing of BMI ( P = 0.04). Moreover, microalbuminuria was significantly higher in people with WHR >1 ( P =0.02). Conclusion : Through this study, we detected the association of microalbuminuria with BMI and WHR. Therefore, efforts must be conducted to reduce obesity through lifestyle changes and regular exercise.
No takes yet. Share an insight, caveat, or question.
Kaseb et al. (2020) conducted a cross-sectional in Overweight and obesity (n=200). Higher body mass index (BMI) and waist-to-hip ratio (WHR) vs. Lower BMI and WHR was evaluated on Prevalence of microalbuminuria (p=0.04). Among overweight and obese adults without diabetes or hypertension, the prevalence of microalbuminuria was 11% and significantly increased with higher body mass index (P=0.04) and waist-to-hip ratio >1 (P=0.02).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: