Key result
Microalbuminuria occurs in ~4% of obese children, linked to higher BMI and waist circumference.
Why the study?
Microalbuminuria is a marker of renal insult in adults but its prevalence and significance in obese children is less understood.
What is the prevalence of microalbuminuria and its relation to obesity parameters in obese children aged 5-18 years?
Cross-Sectional (n=54)
No
What is the prevalence of microalbuminuria and its relation to obesity parameters in obese children aged 5-18 years?
Microalbuminuria has a low prevalence in obese children but is significantly associated with higher BMI and truncal obesity, suggesting these specific high-risk subgroups warrant screening.
Microalbuminuria was associated with higher BMI and waist circumference in obese children; hypothesis-generating for targeted screening, prospective studies needed before practice change.
Background: Obesity is a global pandemic both in adults and children and many factors contribute to this pandemic. Early diagnosis and prevention of long-term complications associated with obesity is the main goal of treatment in addition to dietary control and lifestyle modifications. Microalbuminuria, a marker of impending renal insult in adults is less understood in children. The objective of this study was to determine microalbuminuria in obese children 5-18 years of age.Methods: This study was single centre, and cross-sectional observational study. Children between 5-18 years of age with obesity (Body mass index >95th centile for sex and age) participated in the study. Microalbuminuria based on urinary albumin to creatinine ratio and relation to obesity was studied.Results: Fifty-four children (M:F=0.9:1) were included in the study. Family history of obesity, hypertension, diabetes mellitus was present in 53.7% (n=29), 33.3% (n=18), 27.8 (n=15) children respectively. Microalbuminuria was observed in two children (3.8%). Mean BMI (38.25±7.42 kg/m2 vs 26.13±4.13 kg/m2) (p=0.009), mean waist circumference (97.50±4.95, vs 83.52±0.94 cm) (p=0.044), mean waist hip ratio (0.93±0.04 vs 0.88±0.09) was more in children with microalbuminuria when compared to without microalbuminuria. One obese child with microalbuminuria had hypertension.Conclusions: Microalbuminuria, though a good marker of renal insult in adults, may not be prevalent in obese children. It may me more prevalent in obese children with higher BMI, truncal obesity and WHR, hence these children should be screened for the same.
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Mundkur et al. (2021) conducted a cross-sectional in Obesity (n=54). Obesity was evaluated on Prevalence of microalbuminuria. Microalbuminuria was observed in only 3.8% of obese children, but was associated with significantly higher mean BMI (38.25 vs 26.13 kg/m2, p=0.009) and waist circumference.
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