July 1, 1984Annals of Internal Medicine
Reevaluation of Digitalis Efficacy
Why the study?
Does digitalis improve clinical outcomes in patients with congestive heart failure and sinus rhythm?
Population
Patients with congestive heart failure and sinus rhythm
Comparison
Digitalis (digoxin) therapy vs Placebo or withdrawal of therapy
Design
Systematic_review
Authors
Discussion
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Member takes
Implication
Limited high-quality evidence restricts digitalis use in sinus-rhythm HF; leaves open benefits in select patients pending definitive trials.
Structured PICO
Does digitalis improve clinical outcomes in patients with congestive heart failure and sinus rhythm?
P
Population
Patients with congestive heart failure and sinus rhythm (based on a review of 16 articles from a literature search of 736 articles)
I
Intervention
Digitalis (digoxin) therapy
C
Comparator
Placebo or withdrawal of therapy (in the two highlighted trials)
O
Outcome
Clinical efficacy
A critical appraisal of literature from 1960 to 1982 found very limited high-quality evidence supporting digitalis efficacy in heart failure with sinus rhythm, highlighting the need for better trials.
Cite This Study
Cynthia D. Mulrow (1984) studied this question.