What question did this study set out to answer?

To determine the immediate circulatory and hemodynamic effects of intravenous digoxin in patients with chronic cor pulmonale during acute heart failure and after recovery.

February 1, 1950CirculationOpen Access

Some Effects of Digoxin upon the Heart and Circulation in Man

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Why the study?

Does intravenous digoxin affect the dynamics of the circulation in patients with chronic cor pulmonale?

Population

Patients with chronic cor pulmonale

Design

Case_series

Authors

MFM. IRENÉ FERRERNewYork–Presbyterian Hospital RHRéjane M. HarveyMerck & Co., Inc., Rahway, NJ, USA (United States)RCRichard CathcartMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

Member takes

Implication

May alter hemodynamics in decompensated cor pulmonale; hypothesis-generating and requires prospective validation before any practice consideration.

Key Points

To determine the immediate circulatory and hemodynamic effects of intravenous digoxin in patients with chronic cor pulmonale during acute heart failure and after recovery.
Assessed circulatory dynamics using cardiac catheterization during acute digitalization with intravenous digoxin in patients with chronic cor pulmonale.
Repeated hemodynamic evaluations in the same patient cohort after clinical recovery from heart failure.
Intravenous digoxin administration rapidly alters acute circulatory dynamics and cardiac performance in decompensated cor pulmonale.
Cardiovascular functional states differ significantly between active circulatory failure and post-recovery baseline phases.

Structured PICO

Does intravenous digoxin affect the dynamics of the circulation in patients with chronic cor pulmonale?

Population

Patients with chronic cor pulmonale

Intervention

Intravenous digoxin (acute digitalization)

Outcome

Dynamics of the circulation measured by cardiac catheterizationsurrogate

This study investigates the hemodynamic effects of acute intravenous digoxin in patients with chronic cor pulmonale.

Cite This Study

FERRER et al. (1950) studied this question.

synapsesocial.com/papers/6a8317da114d53034e9c879c https://doi.org/10.1161/01.cir.1.2.161

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Implication

May alter hemodynamics in decompensated cor pulmonale; hypothesis-generating and requires prospective validation before any practice consideration.

Some Effects of Digoxin upon the Heart and Circulation in Man

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Some Effects of Digoxin upon the Heart and Circulation in Man

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider