Key result
Traditional Chinese Medicine formulations may prevent and treat myocardial infarction by regulating Connexin43 expression to improve structural and electrical remodeling of the myocardium.
Why the study?
Cx43 structural and functional damage is central to MI progression and post-MI arrhythmia, making Cx43 regulation an important strategy to improve myocardial remodeling and prognosis.
This review highlights the potential of Traditional Chinese Medicine formulations to regulate Connexin43 expression and improve structural and electrical remodeling following myocardial infarction.
Should not yet change post-MI care; hypothesis-generating for TCM effects on Connexin43 remodeling.
Gap junctions are the main form of interaction between cardiomyocytes, through which the electrochemical activities between cardiomyocytes can be synchronized to maintain the normal function of the heart. Connexins are the basis of gap junctions. Changes in the expression, structural changes (e.g., phosphorylation and dephosphorylation), and distribution of connexins can affect the normal electrophysiological activities of the heart. Myocardial infarction (MI) and concurrent arrhythmia, shock, or heart failure can endanger life. The structural and functional damage of connexin (Cx) 43 in cardiomyocytes is a central part of the pathological progression of MI and is one of the main pathological mechanisms of arrhythmia after MI. Therefore, increasing Cx43 expression has become one of the main measures to prevent MI. Also, intervention in Cx43 expression can improve the structural and electrical remodeling of the myocardium to improve MI prognosis. Here, research progress of Cx43 in MI and its prevention and treatment using Traditional Chinese Medicine formulations is reviewed.
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Liu et al. (2021) conducted a review in Myocardial infarction. Traditional Chinese Medicine formulations was evaluated. Traditional Chinese Medicine formulations may prevent and treat myocardial infarction by regulating Connexin43 expression to improve structural and electrical remodeling of the myocardium.
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