February 8, 2006European Journal of Heart Failure
The Effect of Altering Haemodynamics on the Plasma Concentrations of Natriuretic Peptides in Heart Failure
Why the study?
Does rapid and persistent vasodilatation alter the plasma concentrations of natriuretic peptides in patients with heart failure?
Population
20 patients aged 63.0+/-10.4 with symptomatic congestive heart failure and pulmonary capillary wedge…
Design
Cohort
Follow-up
24 hours
Authors
Discussion
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Implication
Supports differential NP kinetics during vasodilation in HF; leaves open whether serial monitoring refines therapy titration.
Structured PICO
Does rapid and persistent vasodilatation alter the plasma concentrations of natriuretic peptides in patients with heart failure?
P
Population
20 patients (16 men, 4 women) aged 63.0+/-10.4 with symptomatic congestive heart failure (NYHA III) and pulmonary capillary wedge pressure (PCWP) >18 mm Hg
I
Intervention
24-h infusion of nitroglycerin (N=8) or nicorandil (N=12)
O
Outcome
Kinetic profile of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP) and their N-terminal fragments N-ANP and N-BNP over 24 hourssurrogate
Atrial natriuretic peptides reflect rapid changes in cardiac filling pressures, whereas B-type peptides respond more slowly and better reflect changes in systemic vascular resistance during vasodilator therapy.
Cite This Study
Larsen et al. (2006) studied this question.