PI3P regulates multiple stages of membrane fusion

This is the authors' abstract. We don't add key points for this paper.

Using reconstituted fusion with all purified proteins and defined lipids, four targets for PI3P regulation are reported: recruitment of the Qc-SNARE, trans-SNARE assembly between membranes, protection of SNARE complexes from the chaperones Sec17 and Sec18 by the conserved tethering complex HOPS, and fusion per se after tethering.