Key result
Unilateral adrenalectomy resulted in the improvement of Cushing's signs without recurrence for five years in a patient with Carney complex complicated by primary pigmented nodular adrenocortical disease.
Case Report (n=1)
No
Unilateral adrenalectomy may be a viable treatment option for primary pigmented nodular adrenocortical disease in Carney complex patients with mild metabolic abnormalities and poor medication adherence.
Unilateral adrenalectomy may warrant consideration in select Carney complex cases; leaves open need for prospective validation before practice change.
We herein report a case of Carney complex (CNC) complicated with primary pigmented nodular adrenocortical disease (PPNAD) after unilateral adrenalectomy. A 44-year-old woman was admitted to our hospital for PPNAD surgery. She had previously undergone surgery for cardiac myxoma and had a PRKAR1A mutation with no family history of CNC. She had Cushing's signs, but her metabolic abnormalities were mild. Adrenal insufficiency due to poor medication adherence was a concern, so she underwent unilateral adrenalectomy. Cushing's signs improved postoperatively and without recurrence for five years. Treatment plans for PPNAD should be determined based on the patient's condition, medication adherence, and wishes.
No takes yet. Share an insight, caveat, or question.
Tsurutani et al. (2022) conducted a case report in Carney complex complicated with primary pigmented nodular adrenocortical disease (PPNAD) (n=1). Unilateral adrenalectomy was evaluated on Recurrence of Cushing's syndrome. Unilateral adrenalectomy resulted in the improvement of Cushing's signs without recurrence for five years in a patient with Carney complex complicated by primary pigmented nodular adrenocortical disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: