Key result
Sequential bilateral adrenalectomy resulted in complete disease remission, accelerated growth, and reversal of osteopenia in a 7-year-old girl with isolated non-familial PPNAD.
Case Report (n=1)
Bilateral adrenalectomy may be necessary for complete disease remission and growth normalization in pediatric patients with isolated non-familial PPNAD.
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May support adrenalectomy for growth recovery in rare pediatric PPNAD; hypothesis-generating and requires prospective validation before practice change.
Leka et al. (2011) conducted a case report in Cushing syndrome due to isolated non-familial Primary pigmented nodular adrenocortical disease (PPNAD) (n=1). Sequential bilateral adrenalectomy was evaluated on Disease remission and growth. Sequential bilateral adrenalectomy resulted in complete disease remission, accelerated growth, and reversal of osteopenia in a 7-year-old girl with isolated non-familial PPNAD.
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