XII. Yeast sequencing reports. Sequence, mapping and disruption of CCC1, a gene that cross‐complements the Ca²⁺‐sensitive phenotype of csg1 mutants

We have isolated, sequenced, mapped and disrupted a novel gene, CCC1 , from Saccharomyces cerevisiae . This gene displays non‐allelic complementation of the Ca 2+ ‐sensitive phenotype conferred by the csg1 mutation. The ability of this gene, in two copies per cell, to reverse the csg1 defect suggests it may have a role in regulating Ca 2+ homeostasis. The sequence of CCC1 indicates that it encodes a 322 amino acid, membrane‐associated protein. The CCC1 gene is located on the right arm of chromosome XII. The sequence has been deposited in the GenBank data library under Accession Number L24112.