Population
Poliovirus type 2 isolates from paralytic cases associated with vaccination in Japan, specifically detailing…
Design
Case_report
Follow-up
41 months (3.5 years)
Authors
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May signal accelerated poliovirus evolution under secretory IgA in immunocompromised hosts; leaves open causality and broader applicability.
The poliovirus type 2 Sabin vaccine strain genome is highly mutable after passage in humans, with marked changes observed following secretory IgA treatment in an immunocompromised patient.
Yoneyama et al. (1982) studied this question.
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