July 1, 2000Journal of Cardiovascular Electrophysiology
Effect of Chronic Amiodarone Therapy on Defibrillation Energy Requirements in Humans
Why the study?
Does chronic oral amiodarone therapy increase defibrillation energy requirements in patients with implantable defibrillators?
Population
21 consecutive patients with implantable biphasic waveform defibrillators
Comparison
Chronic oral amiodarone therapy vs Baseline
Design
Cohort
Follow-up
73 +/- 22 days after initiation of therapy
Authors
Discussion
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Member takes
Implication
Amiodarone was associated with higher defibrillation thresholds; leaves open whether routine threshold testing or device reprogramming is warranted in ICD patients.
Structured PICO
Does chronic oral amiodarone therapy increase defibrillation energy requirements in patients with implantable defibrillators?
P
Population
21 consecutive patients with implantable biphasic waveform defibrillators
I
Intervention
Chronic oral amiodarone therapy (mean total dose 26.7 +/- 11.1 g)
C
Comparator
Baseline (before amiodarone therapy, 211 +/- 12 days prior)
O
Outcome
Defibrillation energy requirementsurrogate
Chronic oral amiodarone therapy significantly increases defibrillation energy requirements in patients with implantable defibrillators, which correlates with serum drug concentrations.
Cite This Study
Pelosi et al. (2000) studied this question.