Why the study?
Does long-term amiodarone treatment alter ventricular fibrillation vulnerability and defibrillation efficacy in isolated rabbit hearts?
Population
20 isolated perfused hearts of rabbits (n=10 treated, n=10 control)
Comparison
Amiodarone 50 mg/kg/day orally for 28 days prior… vs Control group (n=10)
Design
Preclinical
Follow-up
28 days
Authors
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Rabbit data should not change ULV use as DFT surrogate; leaves open translation to clinical amiodarone therapy.
Does long-term amiodarone treatment alter ventricular fibrillation vulnerability and defibrillation efficacy in isolated rabbit hearts?
Long-term amiodarone treatment does not alter the defibrillation threshold or upper limit of vulnerability in rabbit hearts, suggesting ULV remains a valid surrogate for DFT during amiodarone therapy.
Behrens et al. (1997) studied this question.
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