April 15, 2025European Heart JournalOpen Access

Mitral annular disjunction and mitral valve prolapse: long-term risk of ventricular arrhythmias after surgery

View Full Paper

Ask AI

Bookmark

Why the study?

A subset of patients with MVP experience ventricular arrhythmias, with MAD reported as a risk factor, but the long-term risk of VA after mitral valve surgery for MR was not well established.

Does the presence of pre-operative mitral annular disjunction increase the risk of ventricular arrhythmias in patients with mitral valve prolapse undergoing mitral valve surgery?

Structured PICO

Does the presence of pre-operative mitral annular disjunction increase the risk of ventricular arrhythmias in patients with mitral valve prolapse undergoing mitral valve surgery?

Population

599 patients with mitral valve prolapse (MVP) with moderate or severe degenerative mitral regurgitation (MR) undergoing mitral valve surgery (repair or replacement) in 2010-22 at Karolinska University Hospital.

Intervention

Presence of pre-operative mitral annular disjunction (MAD)

Comparator

Absence of pre-operative mitral annular disjunction (MAD)

Outcome

Ventricular arrhythmias (VA) including hospitalizations, outpatient visits or ablation for confirmed sustained or non-sustained ventricular tachycardia, or high burden of premature ventricular complexes assessed from medical recordscomposite

Pre-operative mitral annular disjunction in patients with MVP and MR is associated with a three-fold increased long-term risk of ventricular arrhythmias post-mitral valve surgery, despite anatomical correction.

Implication

Pre-operative MAD may warrant intensified post-MVP VA surveillance; leaves open whether MAD-targeted strategies improve outcomes.

Abstract

BACKGROUND AND AIMS: Mitral valve prolapse (MVP) is associated with progressive mitral regurgitation (MR) requiring surgical correction. A subset of patients with MVP experience ventricular arrhythmias (VA), and mitral annular disjunction (MAD) has been reported as a risk factor. This study aimed to assess the long-term risk of VA in patients with MAD and MVP undergoing mitral valve surgery for MR. METHODS: Patients with MVP with moderate or severe degenerative MR undergoing mitral valve surgery (repair or replacement) in 2010-22 at Karolinska University Hospital were included. Mitral annular disjunction length, referring to true MAD, was measured at end systole on pre- and post-operative transthoracic echocardiography. The primary outcome consisted of VA including hospitalizations, outpatient visits or ablation for confirmed sustained or non-sustained ventricular tachycardia, or high burden of premature ventricular complexes and assessed from medical records. RESULTS: Of 599 patients undergoing mitral valve surgery, 96 (16%) had pre-operative MAD. The median MAD length was 8.0 [inter-quartile range (IQR) 5.0-10.0] mm. Compared with patients without MAD, patients with MAD were younger (55 ± 15 vs 63 ± 11 years), were more often women (31% vs 17%), and had more Barlow's disease (70% vs 27%). Mitral annular disjunction was surgically corrected in all patients. During a median follow-up time of 5.4 (IQR 2.8-7.5) years, patients with pre-operative MAD had a higher risk of VA (hazard ratio adjusted for age and sex 3.33, 95% confidence interval 1.37-8.08) regardless of repair/replacement (Pinteraction = .18). CONCLUSIONS: Mitral annular disjunction in patients with MVP and MR was associated with a three-fold increased long-term risk of VA post-mitral valve surgery, despite anatomical correction of MAD.