Why the study?
Does carvedilol compared to enalapril affect quality of life in patients with mild to moderate hypertension?
Population
248 patients with mild to moderate hypertension (diastolic blood pressure 95-115 mmHg)
Comparison
Carvedilol for a 5-month maintenance period vs Enalapril for a 5-month maintenance period
Design
RCT, randomised, double-blind
Follow-up
5 months (maintenance period)
Authors
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Carvedilol preserves quality of life with less cough than enalapril; reinforces beta-blocker preference in cough-sensitive hypertension.
Does carvedilol compared to enalapril affect quality of life in patients with mild to moderate hypertension?
Carvedilol and enalapril provide similar blood pressure control without adversely affecting quality of life, though enalapril causes more cough.
Östergren et al. (1996) studied this question.
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