Why the study?
Does aminoguanidine attenuate proteinuria in a rat model of chronic renal disease?
Does aminoguanidine attenuate proteinuria in a rat model of chronic renal disease?
Inhibition of nitric oxide synthase with aminoguanidine attenuates proteinuria in a rat model of chronic renal disease, suggesting its involvement in disease progression.
Hypothesis-generating in rat models; leaves open any role for aminoguanidine in human chronic kidney disease.
The present study demonstrates that the nitric oxide synthase inhibitor, aminoguanidine, can attenuate the proteinuria observed in a predominantly noninflammatory model of chronic renal disease in the rat. These data suggest that nitric oxide synthase may be involved in progressive renal disease.
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Brooks et al. (1998) studied this question.
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