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January 1, 1998HypertensionOpen Access

Inducible Nitric Oxide Synthase and Blood Pressure

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Population

Sprague-Dawley rats.

Comparison

Aminoguanidine intravenous infusion, with or… vs Vehicle-infused control animals and pre-infusion…

Design

Preclinical

Follow-up

6 days

Authors

DMDavid L. MattsonAugusta UniversityCMCelso Y. MaedaSemmelweis UniversityTBTimothy D. BachmanMedical College of Wisconsin

Discussion

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Implication

Rat data implicate iNOS in BP regulation; leaves open relevance to human hypertension.

Structured PICO

P
Population
Sprague-Dawley rats (n=31 total across experiments, including anesthetized normal rats and uninephrectomized rats on a 4.0% NaCl high salt diet).
I
Intervention
Aminoguanidine (inducible NOS inhibitor) intravenous infusion (60 mg/kg/hr for 40 minutes or 10 mg/kg/hr chronically for 6 days), with or without oral L-arginine.
C
Comparator
Vehicle-infused control animals and pre-infusion baseline.
O
Outcome
Mean arterial pressure and renal function (urine flow, renal cortical and medullary blood flow).surrogate

Inhibition of inducible nitric oxide synthase with aminoguanidine increases blood pressure in rats, suggesting a role for iNOS in arterial pressure regulation.

Cite This Study

Mattson et al. (1998) studied this question.

synapsesocial.com/papers/6a856aaa35bc0eada8d59cf1https://doi.org/10.1161/01.hyp.31.1.15
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Also Consider

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  1. 1Role of nitric oxide in regulation of long-term pressure-natriuresis relationship in Dahl rats1995 · 108 citations
  2. 2Topography of nitric oxide synthesis by localizing constitutive NO synthases in mammalian kidney1995 · 363 citations
  3. 3Polymerase chain reaction localization of constitutive nitric oxide synthase and soluble guanylate cyclase messenger RNAs in microdissected rat nephron segments.1992 · 246 citations
  4. 4Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.1989 · 1,851 citations
  5. 5Aminoguanidine‐provoked leukocyte adherence to rat mesenteric venules: role of constitutive nitric oxide synthase inhibition1995 · 32 citations