June 1, 1985Molecular and Cellular BiologyOpen Access

Expression of a Human U1 RNA Gene Introduced into Mouse Cells via Bovine Papillomavirus DNA Vectors

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Population

Mouse C127 cells

Design

Preclinical

Authors

ESElaine T. SchenbornUniversity of Wisconsin–Madison ELElsebet LundUniversity of Wisconsin System JMJacque MitchenArgonne National Laboratory

Discussion

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Implication

Hypothesis-generating for BPV-driven human snRNA expression in mammalian cells; leaves open therapeutic translation pending in vivo validation.

Structured PICO

Population

Mouse C127 cells

Intervention

Introduction of human U1 small nuclear RNA gene (HU1-1) via bovine papillomavirus (BPV) vectors

Outcome

Expression levels of human U1 RNAsurrogate

This preclinical study demonstrates successful expression of human U1 RNA in mouse cells using BPV vectors, requiring minimal flanking sequences for transcription.

Cite This Study

Schenborn et al. (1985) studied this question.

synapsesocial.com/papers/6a832837c91fb0067aa502e7 https://doi.org/10.1128/mcb.5.6.1318-1326.1985

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Implication

Hypothesis-generating for BPV-driven human snRNA expression in mammalian cells; leaves open therapeutic translation pending in vivo validation.

Expression of a Human U1 RNA Gene Introduced into Mouse Cells via Bovine Papillomavirus DNA Vectors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Expression of a Human U1 RNA Gene Introduced into Mouse Cells via Bovine Papillomavirus DNA Vectors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider