Why the study?
Does levosimendan improve left ventricular systolic and diastolic functions compared to dobutamine in chronic heart failure patients treated chronically with carvedilol?
Population
40 patients with chronic heart failure, NYHA class III to IV symptoms, LVEF <40%, and ongoing treatment with…
Comparison
Levosimendan vs Dobutamine
Design
RCT, 1:1, open-label
Follow-up
24 hours
Authors
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Supports preferring levosimendan over dobutamine for LV function in carvedilol-treated decompensated HF; extends inotrope comparisons to beta-blocked patients.
Does levosimendan improve left ventricular systolic and diastolic functions compared to dobutamine in chronic heart failure patients treated chronically with carvedilol?
In patients with decompensated heart failure on chronic carvedilol therapy, levosimendan significantly improves left ventricular systolic and diastolic function, whereas dobutamine does not.
Duygu et al. (2008) studied this question.
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