An efficient, metal‐free Brønsted acid‐catalyzed, enantioselective hydrocyanation of ketoimines has been developed. This BINOL phosphate‐catalyzed Strecker reaction provides the corresponding amino nitriles, precursors of quaternary amino acids, in good isolated yields and enantioselectivities. Additionally, we demonstrate that chiral diols, such as TADDOL, are effective enantioselective catalysts for the hydrogen‐bond activation of aldimines.
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Rueping et al. (2007) studied this question.
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