What question did this study set out to answer?

To determine whether triglycerides represent an appropriate therapeutic target for the primary or secondary prevention of atherosclerotic cardiovascular disease based on clinical trial evidence.

October 1, 2000European Journal of Cardiovascular Prevention & RehabilitationOpen Access

Triglycerides and Coronary Heart Disease: Implications of Recent Clinical Trials

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Implication

Clinical trial review reveals selective cardiovascular benefits of fibrate therapy in patients with hypertriglyceridemia and low HDL, suggesting targeted rather than universal intervention.

Key Points

To determine whether triglycerides represent an appropriate therapeutic target for the primary or secondary prevention of atherosclerotic cardiovascular disease based on clinical trial evidence.
Reviewed findings from two angiographic trials: the Lopid Coronary Angiography Trial (LOCAT) and the Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT).
Evaluated outcomes from three clinical endpoint trials: the Helsinki Heart Study (HHS), the Bezafibrate Infarction Prevention (BIP) study, and the VA HDL Intervention Trial (VA-HIT).
Hypertriglyceridemia alone is not an appropriate primary therapeutic target, as no clinical trials directly show that lowering isolated triglyceride levels reduces clinical cardiovascular events.
Fibrate therapy demonstrated clinical benefit in patients with established coronary heart disease who had elevated triglycerides combined with low HDL-cholesterol or metabolic syndrome components like diabetes and obesity.
In individuals without established coronary heart disease, elevated triglycerides act primarily as a risk marker indicating the need for aggressive control of hypertension, diabetes, obesity, and LDL-cholesterol.

Cite This Study

A 2000 study studied this question.

synapsesocial.com/papers/6a83317f6f989a47dda508c4 https://doi.org/10.1177/204748730000700507

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Implication

Clinical trial review reveals selective cardiovascular benefits of fibrate therapy in patients with hypertriglyceridemia and low HDL, suggesting targeted rather than universal intervention.

Triglycerides and Coronary Heart Disease: Implications of Recent Clinical Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

Triglycerides and Coronary Heart Disease: Implications of Recent Clinical Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

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