Why the study?
Does sodium hydrosulfide (NaHS) prevent the development of hypertension in l-NAME-induced hypertensive rats?
Population
Wistar rats with hypertension induced by oral administration of l-NAME in drinking water for 6 weeks
Comparison
Sodium hydrosulfide given by intraperitoneal… vs l-NAME alone (and plain tap water controls)
Design
Preclinical
Follow-up
6 weeks
Authors
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Extends H2S pathway evidence in rat hypertension models; leaves open any human therapeutic role.
Does sodium hydrosulfide (NaHS) prevent the development of hypertension in l-NAME-induced hypertensive rats?
Exogenous hydrogen sulfide effectively prevents the development of hypertension induced by l-NAME in rats, suggesting the H2S pathway participates in hypertension pathogenesis.
Zhong et al. (2003) studied this question.
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