January 1, 1999Cellular Physiology and Biochemistry

Molecular Basis, Pharmacology and Physiological Role of Cardiac KATP Channels

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Why the study?

Does HMR 1883 prevent ventricular fibrillation in a conscious dog model?

Population

Conscious dog model

Design

Preclinical

Authors

HGHeinz GögeleinSanofi (France)JHJens HartungUniversity of Kaiserslautern HEHeinrich EnglertUniversität Hamburg

Discussion

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Implication

May support cardioselective K(ATP) blockade for VF prevention in ischemia; leaves open human translation.

Structured PICO

Does HMR 1883 prevent ventricular fibrillation in a conscious dog model?

Population

Conscious dog model

Intervention

HMR 1883 (cardioselective K(ATP) channel blocker)

Outcome

Prevention of ventricular fibrillationsurrogate

HMR 1883 is a cardioselective K(ATP) channel blocker that shows potential as a novel drug candidate for preventing ischemia-induced ventricular fibrillation and sudden cardiac death.

Cite This Study

Gögelein et al. (1999) studied this question.

synapsesocial.com/papers/6a83333fb9768edacab38194 https://doi.org/10.1159/000016319

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Molecular Basis, Pharmacology and Physiological Role of Cardiac KATP Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular Basis, Pharmacology and Physiological Role of Cardiac KATP Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider