Clarithromycin may be associated with QT prolongation and torsades de pointes even in the absence of other QT-prolonging medications.
Clarithromycin may trigger TdP without other QT agents; case reports leave open causality and need prospective confirmation.
Two cases of QT prolongation and torsades de pointes (TdP) are presented. The patients had been taking clarithromycin (400 mg/day) for respiratory disease. Although erythromycin is reportedly associated with TdP, this is the first report of clarithromycin associated with TdP in the absence of other drugs already known to produce QT prolongation.
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Kamochi et al. (1999) studied this question.
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