Population
Guinea-pig ventricular cells
Comparison
Nitrendipine (100 nM) vs Control (absence of nitrendipine)
Design
Preclinical
Authors
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Mechanistic detail on nitrendipine's state-dependent Ca-channel block in guinea-pig myocytes; leaves open translation to human ventricular electrophysiology.
Nitrendipine blocks calcium channels in guinea-pig ventricular cells by prolonging the unavailable states initiated by drug binding during depolarization.
Kawashima et al. (1988) studied this question.
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