Population
GH4C1 clonal cell line derived from rat anterior pituitary cells
Design
Preclinical
Authors
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May inform state-dependent Ca channel pharmacology; leaves open translation to human endocrine function or therapy.
Nimodipine preferentially blocks slowly inactivating calcium channels in rat anterior pituitary cells via a time- and voltage-dependent mechanism, suggesting minimal effect on normal stimulus-secretion coupling in vivo.
Cohen et al. (1987) studied this question.
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