January 1, 1988The Japanese Journal of PharmacologyOpen Access

Characteristics of 3HNimodipine Binding to Sarcolemmal Membranes from Rat Vas Deferens and Its Regulation by Guanine Nucleotide

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Population

Microsomal fraction from rat vas deferens

Design

Preclinical

Authors

KHKatsuya HigoKyowa Kirin (Japan)HSHiroshi SaitōNTT Medical Center NMNorio MatsukiThe University of Tokyo

Discussion

Member takes

Implication

Nimodipine's single high-affinity site in rat membranes warrants clinical caution; leaves open G-protein involvement in human Ca2+ channel function.

Structured PICO

Population

Microsomal fraction from rat vas deferens

Intervention

[3H]nimodipine

Outcome

Binding properties (dissociation constant and maximum number of binding sites)surrogate

Nimodipine binds to a single site on rat vas deferens sarcolemmal membranes closely related to the functional Ca2+ channel, with signal transduction potentially involving a guanine nucleotide binding protein.

Cite This Study

Higo et al. (1988) studied this question.

synapsesocial.com/papers/6a8a824981f71cbdf7de85da https://doi.org/10.1254/jjp.48.213

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Implication

Nimodipine's single high-affinity site in rat membranes warrants clinical caution; leaves open G-protein involvement in human Ca2+ channel function.

Characteristics of 3HNimodipine Binding to Sarcolemmal Membranes from Rat Vas Deferens and Its Regulation by Guanine Nucleotide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characteristics of 3HNimodipine Binding to Sarcolemmal Membranes from Rat Vas Deferens and Its Regulation by Guanine Nucleotide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider