Why the study?
Does nitroglycerin improve regional coronary blood flow distribution in ischaemic canine myocardium?
Does nitroglycerin improve regional coronary blood flow distribution in ischaemic canine myocardium?
Nitroglycerin helps redistribute capillary blood flow towards normal in an ischaemic canine model.
Answers are grounded in this paper and cite their sources.
Preclinical canine data do not change practice; leaves open translation of flow redistribution to human ischemia.
The effect of nitroglycerin on total coronary flow and its regional distribution was determined in normal conditions and in myocardial ischaemia. In normal hearts, capillary flow was 9·5% higher in the inner than in the outer myocardial half. When partial occlusion of coronary arteries was followed by infusion of noradrenaline, subendocardial flow was less than capillary flow in subepicardial layers. In these conditions, the administration of nitroglycerin resulted in a redistribution of capillary flow towards normal.
No takes yet. Share an insight, caveat, or question.
Mathes et al. (1971) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: