What question did this study set out to answer?

To compare the variability of systemic, proximal, and distal blood flow measurements between left-atrial and left-ventricular microsphere injections in rats.

January 1, 1982AJP Heart and Circulatory Physiology

Importance of injection site for coronary blood flow determinations by microspheres in rats

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Why the study?

Does left-atrial injection of microspheres reduce the variability of coronary blood flow determinations compared to left-ventricular injection in anesthetized rats?

Population

Anesthetized rats

Comparison

Left-atrial (LA) injection of microspheres vs Left-ventricular (LV) injection of microspheres

Design

Preclinical

Authors

PWP WickerBoston University RTRobert C. TaraziGeneral / Preventive / Lipids

Discussion

Member takes

Implication

LA injection may offer more precise coronary flow measurements in rat models; leaves open translation to other species or clinical use.

Key Points

To compare the variability of systemic, proximal, and distal blood flow measurements between left-atrial and left-ventricular microsphere injections in rats.
Developed a technique for left-atrial (LA) catheterization in anesthetized rats.
Measured cardiac output, proximal flow (coronary blood flow), and distal flows (renal, cerebral) following either LA or left-ventricular (LV) microsphere injection.
Coronary blood flow averaged 410 ± 224 ml·min⁻¹·100 g⁻¹ (5.7 ± 2.9 %CO) with LV injection compared to 358 ± 99 ml·min⁻¹·100 g⁻¹ (4.9 ± 1.3 %CO) with LA injection.
LA injection demonstrated significantly lower measurement variability for coronary blood flow than LV injection (SD 99 vs. 224 ml·min⁻¹·100 g⁻¹; P > 0.01).
Variability in cardiac output and distal regional flows (renal and cerebral) showed no significant differences between injection sites.

Structured PICO

Does left-atrial injection of microspheres reduce the variability of coronary blood flow determinations compared to left-ventricular injection in anesthetized rats?

Population

Anesthetized rats

Intervention

Left-atrial (LA) injection of microspheres

Comparator

Left-ventricular (LV) injection of microspheres

Outcome

Variability of coronary blood flow (CBF) determinationssurrogate

Left-atrial injection of microspheres provides less variable and more accurate measurements of coronary blood flow in rats compared to left-ventricular injection.

Cite This Study

Wicker et al. (1982) studied this question.

synapsesocial.com/papers/6a8336c595f6f1aefa9c993b https://doi.org/10.1152/ajpheart.1982.242.1.h94

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Importance of injection site for coronary blood flow determinations by microspheres in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Importance of injection site for coronary blood flow determinations by microspheres in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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