Key result
LV microsphere injection yields coronary blood flow values similar to LA injection.
Why the study?
Does microsphere injection into the left ventricle provide comparable coronary blood flow measurements to left atrial injection in rats?
Population
Semiconscious rats
Comparison
Simultaneous injection of radiolabeled… vs Simultaneous injection of radiolabeled…
Design
Preclinical
Authors
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LV microsphere injection matches LA for coronary flow in rats; challenges prior variability reports but leaves open translation beyond this model.
Does microsphere injection into the left ventricle provide comparable coronary blood flow measurements to left atrial injection in rats?
Absolute Event Rate: 5.24% vs 5.45%
p-value: p=not significantly different
Measurements made by LV microsphere injection provide coronary blood flow data with variability not significantly different from that of left atrial injection in a rat model.
Schrock et al. (1990) studied this question. Microsphere injection into the left ventricle vs. Microsphere injection into the left atrium was evaluated on Coronary blood flow (CBF) values (ml.min-1.g-1) (p=not significantly different). Simultaneous microsphere injection into the left ventricle yielded coronary blood flow values (5.24 +/- 0.46 ml.min-1.g-1) not significantly different from left atrial injection (5.45 +/- 0.43).
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